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KMID : 0377519830080020151
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Chung-Ang Journal of Medicine
1983 Volume.8 No. 2 p.151 ~ p.157
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Effect of Korean Poisonous Snake Venom on Cardiac Contractility
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Lim Jin-Young
Bang Hyo-Weon
Uhm Dae-Yong
Rhee Sang-Don
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Abstract
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In order to observe the effect of the freeze-dried saliva from Korean poisonous snake, Agkistrodon blomhoffii brevicaudus, on the cardiac contractility a ventricular strip was prepared from a frog and its isometric contraction was recorded in a in-vitro chamber containing modified frog Ringer solution with propranolol of 10^-7M/L. The change of the isometric contraction was observed in various concentrations of the snake venom in a condition showing the maximum contractility. Results were as follows: 1. Maximum tension was developed at the stimulation frequency of 0.3~0.6 Hz and the tension rather decreased with the increment of the driving frequency above the range. 2. The contractility increased with increase of outside calcium ion up to 1.1mM in which showed the maximum and then decreased above 1.1mM. 3. In accordance with the increase of the venom dose, the contractility decreased to the venom concentration of 32㎍/ml in which showed the maximum and the half-maximal effect was usually observed around the venom concentration of 1~4㎍/ml. 4. In the venom concentration of 4㎍/ml, the relationship between the outside calcium and contractility shifted to the left. The above results showed that the Korean poisonous snake venom significantly decreased the cardiac contractility to be one of the possible mechanism of the death. the plausible mechanism might be related with the facilitation of a calcium for calcium ions to flow into the cell across the cardiac muscle cell membrane.
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